Rumor has it that Sam Raimi is considering Rachel McAdams for the part of the Felicia Hardy, the Black Cat, in Spider-Man 4.
Fans recall that when Spidey first encounters the Black Cat, she's a cat burglar looking to free her ailing father from prison. She becomes smitten with the web-slinger, to the point of a stalker-level obsession. Later stories had Peter reciprocating her affection and her becoming a lover, a friend and ally (the perfect thing to allow Sony to create a Spidey spin-off).
Rumor also has it that Raimi is looking to cast a male villain for the fourth film, a marked departure from any single-villain