Ryan Seacrest to Make Debut Film With Reese Witherspoon

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LOS ANGELES, CA - MAY 23: TV personality Ryan Seacrest poses at Simon Fuller's Hollywood Walk of Fame star presentation ceremony at Hollywood & Vine on May 23, 2011 in Los Angeles, California. (Photo by Kevin Winter/Getty Images) Photo: Kevin Winter/Getty Images

Both Seacrest and Witherspoon's production companies will produce the film, a romantic comedy, which will be written by Grey's Anatomy scribe Krista Vernoff. [THR]