In the sci-horror film Splice, scientists Sarah Polley and Adrien Brody make the mistake of screwing with the genome. This rarely goes well. The pair mix human and animal DNA until they’ve created Dren, a rapidly aging, humanoid creature with flawless skin and wide-set eyes. (David Edelstein has more to say on Dren, and the film, here.) Of course, Dren is just the latest baby with a mashed-up genetic profile: In the movies, human DNA has been mixed with everything from aliens to vampires, zombies, the devil, and more. Take a look at the creepiest of Dren’s predecessors, in all their gooey, horrifying glory, in this slideshow.