Amy Sedaris is returning to TV with her first regular TV gig since her cult hit series Strangers with Candy went off the air in 2000. Adult Swim just announced today that Sedaris has been added to the cast of its nightmarish live-action 11-minute comedy series, The Heart, She Holler, which debuted as a six-part miniseries in November of 2011 but has been renewed for a second season. The PFFR-produced show also stars Patton Oswalt, Heather Lawless, and Joe Sikora and follows a cartoonish, inbred Southern family. Sedaris will be playing oversexed sister Hurshe Heartshe, the role that comedian Kristen Schaal played in Season One. Adult Swim confirms that Sedaris is taking over the part because Schaal was unavailable for the production schedule. Regardless, it’ll be great to see the very talented Amy Sedaris back on TV on a regular basis whenever Adult Swim debuts The Heart, She Holler’s new season.